Polyglutamine fibrillogenesis: The pathway unfolds
نویسندگان
چکیده
منابع مشابه
Polyglutamine fibrillogenesis: the pathway unfolds.
N ine neurodegenerative diseases are caused by expanding CAG repeats coding for polyglutamine (polyGln) (1–4). These include Huntington’s disease, dentatorubral and pallidoluysian atrophy, several forms of spino-cerebellar ataxia, and spinal and bulbar muscular atrophy. Within the central nervous system, each disease has a distinctive pattern of degeneration, with considerable overlap among the...
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The middle of 2007 saw what may, with time, turn out to be the single most important discovery in the genetics of cardiovascular diseases. Within a few weeks, 4 independent genomewide association studies reported the association of the same locus on chromosome 9p21 with coronary artery disease (CAD) and myocardial infarction (MI).1– 4 In fact, of the hundreds of thousands single-nucleotide poly...
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sites near the ends are most accessible, but even sites near the center of the nucleosome can be attacked, National Institute of Diabetes and Digestive and Kidney Diseases though less readily. The results are consistent with a free energy of binding of DNA to the nucleosome surface National Institutes of Health Bethesda, Maryland 20892-0540 of 0.1–0.15 kcal/mol bp in the range of ionic strength...
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The polyglutamine (polyQ) diseases consist of nine neurodegenerative diseases in which a polyQ tract expansion leads to protein misfolding and subsequent aggregation. Even when the causative proteins have the same length polyQ tract, there are differences in the severity and age of disease onset which implicate the polyQ flanking sequences as modulators of disease. Recent studies on the polyQ p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0237018100